Endocrine Abstracts

Background: Monogenic diabetes is a rare form of diabetes which accounts for 5% of all diabetes cases. This is caused by a single gene mutation mostly inherited from an autosomal dominant pattern. The two types of monogenic diabetes are Neonatal monogenic diabetes (NMD) and Maturity-onset diabetes of the young (MODY). Accurate diagnosis of monogenic diabetes remains to be a great challenge for most clinicians due to its overlapping clinical features from other forms of diabete...

Background: Oral semaglutide GLP1 receptor agonist is coformulated for better absorption compared to prior injectable semaglutide. Phase 2 open label, dose escalation randomized clinical trials of semaglutide and liraglutide investigating the dose-response relationship between the two. DPP-4 inhibitor produces a smaller glycemic reduction and minimal weight reduction through effect of endogenous GLP-1 receptor activity, while GLP-1RAs yield greater efficacy related to the phar...